Architecture and assembly of the T3SS injectisome
Gram-negative bacteria are a family of pathogens including E.coli, Salmonella, Shigella, Pseudomonas aeruginosa, and Yersinia pestis. These bacteria are responsible for a wide range of diseases, from gastro-intestinal infections to the plague. A common trait shared by these bacteria is their capacity to inject toxins directly inside the cells of infected individuals, thanks to a syringe-shaped "nano-machine" called the Type 3 Secretion System (T3SS) injectisome. These toxins leads to modifications of the host cell, allowing the bacteria to replicate efficiently and/or to evade the immune system, and are necessary to establish an infection. As a consequence, preventing the injectisome from performing its function, i.e. injecting the toxins, would effectively prevent the bacteria from causing a disease. As such, the injectisome is an important potential target for the development of novel therapeutics against bacterial infection.
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