Bergeron lab
@ the University of Sheffield

Structure and mechanism of macromolecular nano-machines

List of publications


    Worrall LJ, Hong C, Vuckovic M, Bergeron JRC, Majewski DD, Huang RK, Spreter T, Finlay BB, Yu Z, Strynadka NCJ. Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body. Nature 2016

    Wong LH, Sinha S, Bergeron JR, Mellor JC, Giaever G, Flaherty P, Nislow C. Reverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target Interactions. PLoS Genetics 2016.

    Bergeron JR, Hutto R, Ozyamak E, Hom N, Hansen J, Draper O, Byrne ME, Keyhani S, Komeili A, Kollman JM. Structure of the Magnetosome-associated actin-like MamK filament at sub-nanometer resolution. Protein Science 2016.

    Bergeron JRC. Structural modeling of the flagellum MS ring protein FliF reveals similarities to the type III secretion system and sporulation complex. PeerJ 2016.

    Bergeron JR, Fernández L, Wasney GA, Vuckovic M, Reffuveille F, Hancock RE, Strynadka NC. The Structure of a T3SS Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing. Journal of  Biological Chemistry 2015.

    Dicks MD, Goujon C, Pollpeter D, Betancor G, Apolonia L, Bergeron JR, Malim MH. Oligomerization requirements for MX2 mediated suppression of HIV-1 infection. Journal of Virology 2015.

    Solomonson M, Setiaputra D, Makepeace KAT, Lameignere E, Petrotchenko EV, Conrady DG, Bergeron JR, Vuckovic M, DiMaio F, Borchers CH, Yip CK, Strynadka NCJ. Structure of EspB from the ESX-1 Type VII Secretion System and Insights into its Export Mechanism. Structure 2015.

    Bergeron JRC, Sgourakis NG. Type IV Pilus: One Architectural Problem, Many Structural Solutions. Structure 2015.

    Bergeron JR, Worrall LJ, De S, Sgourakis NG, Cheung AH, Lameignere E, Okon M, Wasney GA, Baker D, McIntosh LP, Strynadka NC. The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body. Structure 2014.

    Lu Z, Bergeron JR, Atkinson RA, Schaller T, Veselkov DA, Oregioni A, Yang Y, Matthews SJ, Malim MH, Sanderson MR. Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction. Open Biology 2013.

    Worrall LJ, Bergeron JRC, Strynadka NCJ. Type III secretion systems. In: Escherichia coli: Pathotypes and Principles of Pathogenesis, 2nd Edition. Edited by Michael Donnenberg. Academic Press 2013.

    Bergeron JR, Worrall LJ, Sgourakis NG, DiMaio F, Pfuetzner RA, Felise HB, Vuckovic M, Yu AC, Miller SI, Baker D, Strynadka NC. A refined model of the prototypical Salmonella SPI-1 T3SS basal body reveals the molecular basis for its assembly. PLoS Pathogens 2013.

    Thanabalasuriar A, Bergeron J, Gillingham A, Mimee M, Thomassin JL, Strynadka N, Kim J, Gruenheid S. Sec24 interaction is essential for localization and virulence-associated function of the bacterial effector protein NleA. Cell Microbiology 2012.

    Sherer NM, Swanson CM, Hué S, Roberts RG, Bergeron JR, Malim MH. Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication. PLoS Pathogens 2011.

    Lu D, Fillet S, Meng C, Alguel Y, Kloppsteck P, Bergeron J, Krell T, Gallegos MT, Ramos J, Zhang X. Crystal structure of TtgV in complex with its DNA operator reveals a general model for cooperative DNA binding of tetrameric gene regulators. Genes & Develepment 2010.

    Autore F, Bergeron JR, Malim MH, Fraternali F, Huthoff H. Rationalisation of the differences between APOBEC3G structures from crystallography and NMR studies by molecular dynamics simulations. PLoS One 2010.

    Ramboarina S, Garnett JA, Zhou M, Li Y, Peng Z, Taylor JD, Lee WC, Bodey A, Murray JW, Alguel Y, Bergeron J, Bardiaux B, Sawyer E, Isaacson R, Tagliaferri C, Cota E, Nilges M, Simpson P, Ruiz T, Wu H, Matthews S. Structural insights into serine-rich fimbriae from Gram-positive bacteria. Journal of  Biological Chemistry 2010.

    Bergeron JR, Huthoff H, Veselkov DA, Beavil RL, Simpson PJ, Matthews SJ, Malim MH, Sanderson MR. The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex. PLoS Pathogens 2010.

    Carpenter EP, Corbett A, Thomson H, Adacha J, Jensen K, Bergeron J, Kasampalidis I, Exley R, Winterbotham M, Tang C, Baldwin GS, Freemont P. AP endonuclease paralogues with distinct activities in DNA repair and bacterial pathogenesis. EMBO Journal 2007.

    Latest News

    22/12/16 - The cryo-EM structure of the T3SS basal body has been published in the journal Nature:

    02/12/16 - I am recruiting a PhD student to join my (forthcoming) lab in the Department of Molecular Biology and Biotechnology at the University of Sheffield, UK. Interested candidates should apply here.

    30/10/16 - I will be giving a talk at the Sheffield Imagine: Imaging Life launch symposium, in January 2017: